The right strategy with these shamanic hallucinogens is this effort to see them as intervention into ordinary brain chemistry.
It’s absolutely central to an intelligent species to have a symbiotic relationship with the matrix of life on its planet. Otherwise, the intelligent species will quickly elaborate a set of lethal cultural adaptations which will have negative feedback into the planetary life system—precisely the situation in which we find ourselves. Intelligence on the surface of a planet must be mediated by a symbiotic relationship with the rest of the living world.